By Puja Gupta
June 11, 2020 (IANSlife) Fertility, in men of advanced age, is becoming an increasing threat as more couples are choosing to defer having children at later stages of their life. A woman's age plays a key role in her ability to get pregnant, but often many of us tend to ignore the fact that a man’s age is equally important.
A woman’s age has long been heralded as the primary factor affecting a couple’s ability to conceive, but is it true time is always on Dad’s side? Does a man’s age affect his ability to produce offsprings and are there any implications for the child? In short, does a man's age matter? IANSlife spoke to Dr. Beena Muktesh, Clinical Director – Fertility, Cloudnine Group of Hospitals, Gurgaon to get the answers.
Does a man's age affect fertility?
Muktesh: People are marrying later, focusing on advancing their careers before considering having children, optionally deciding to have children later in life. Advances in assisted reproductive technology (ART) have provided renewed hope to older parents who want to grow their family but are experiencing fertility issues.
Older men tend to have older partners. Female fertility starts to decline after the age of 30, dropping more sharply after the age of 35. The older your partner, the more difficult it may be to conceive. However, men continue to produce sperm well into middle age and older, providing a more gradual impact on a man’s infertility.
Sperm quality tends to decrease with age. In particular, the shape (morphology) and movement (motility) of your sperm are both likely to deteriorate as you get older, making it more difficult for them to fertilise an egg. You may also produce less sperm as you age. As men age, their sperm undergoes genetic mutations influencing fertility and also creating potential impacts on the physical and mental health of their future children. Conventional wisdom has held men don’t have a biological clock when it comes to their sperm and producing an offspring however with the current lifestyle changes, men need to understand – their biological clock is ticking as well.
Illnesses that decrease fertility are more common among older men. Certain medications for later-life medical problems can also interfere with fertility.
When should a man be concerned his age may have an impact on his progeny’s health?
Muktesh: One of the studies done in 2010 observed the offspring of men over forty had a five-fold risk of developing Autism Spectrum Disorder (ASD) compared to the general population. While the relative number may be disconcerting, given the rarity of ASD, what it means in absolute terms is roughly three in one thousand newborns.
Another study done of 14,000 patients discovered children born to men over 50-years-old developed bipolar disorder 37 percent more compared to the general population. Bipolar disorder is relatively uncommon putting the absolute risk level under 2 percent. There is currently a lack of understanding on the impacts of older paternal age on male fertility and the health of their progeny. Unfortunately, certain genetic conditions do seem to be more common among babies with older fathers. You may be at a slightly increased risk of having a baby with the following conditions as you get older, particularly in your 40s and beyond.
Another study from Israel looked into the relationship between the older age of fathers and the development of schizophrenia among their adult children. The study concluded schizophrenia may be partially linked to genetic changes in a father’s sperm cells. The results displayed a gradual rise in progressive risk with a spike occurring after paternal age passed 50-years-old. Although recent individual studies support the link between the genetic mutations in the sperm of older men and the increased risk of mental disorders among their children, experts remain uncertain if age is the leading cause of these problems, given the vast majority of the illnesses are very rare.
As you age, your sperm is more likely to contain damaged DNA, which can make it more difficult to have a healthy baby. Your partner’s eggs have a built-in mechanism that can repair damaged DNA introduced by sperm. But the older she is, the less effective this will be. That's why some of the risks of genetic disorders only matter when both the mum and dad are older.
What can you do to protect your fertility with age?
Muktesh: Happily, there’s plenty that you can do to keep your fertility and potency in tip-top condition. The following can all help to safeguard your chances of conceiving a healthy baby:
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